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Emmanuel Farge

by sur octobre 10, 2011

Mardi 18 Octobre, à 17h  nous accueillons Emmanuel Farge.

Pour préparer la séance:

Farge, E. (2009) : L’embryon sous l’emprise des gènes et de la pression,  in Pour la Science, vol. 379, pp. 42-49.

Fernandez-Sanchez, M., E., Serman, F., Ahmadi, P., Farge, E. (2010) : Mechanical induction in embryonic development and tumor growth integrative cues through molecular to multicellular interplay and evolutionary perspectives, in Methods Cell Biol., vol. 98, pp. 295-321.

Mechanical Induction in Embryonic Development and Tumour Growth: Integrative Cues through Molecular to Multi-cellular Interplay, and Evolutionary Perspectives.

Emmanuel Farge

Institut Curie (UMR 168 Physico-Chimie)

RÉSUMÉ: Embryonic development is a coordination of multi-cellular biochemical patterning and morphogenetic movements. Last decades revealed the close control of Myosin-II dependent biomechanical morphogenesis by patterning gene expression, with constant progress in the understanding of the underlying molecular mechanisms. Reversed control of developmental gene expression and of Myosin-II patterning by themechanical strains developed y morphogenetic movements was recently revealed at Drosophila gastrulation, through mechano-transduction processes involving the Armadillo/b-catenin and the down-stream of Fog Rho pathways. Here we present the theoretical (simulations integrating the accumulated knowledge in the genetics of earlyembryonic development and morphogenesis), and the experimental (genetic andbiophysical control of morphogenetic movements) tools having allowed the uncoupling of pure genetic inputs from pure mechanical inputs in the regulation of gene expression and Myosin-II patterning. Specifically, we describe the innovative magnetic tweezers tools we have set up to measure and apply physiological strains and forces in vivo, from the inside of the tissue, to modulate and mimic morphogenetic movements in living embryos. We discuss mechanical induction incidence in tumour development, and perspective in evolution.

Références :

Farge, E., « L’embryon sous l’emprise des gènes et de la pression », in Pour la Science, vol. 379, pp. 42-49, 2009.

Fernandez-Sanchez, M., E., Serman, F., Ahmadi, P., Farge, E., « Mechanical induction in embryonic development and tumor growth integrative cues through molecular to multicellular interplay and evolutionary perspectives » in Methods Cell Biol., vol. 98, pp. 295-321, 2010.

Pouille, P.-A. & Farge, E., « Hydrodynamic simulation of multicellular embryo invagination », in Phys. Biol., vol. 5, p. 15005, 2008.

Pouille, P.-A., Ahmadi, P., Brunet, A.-C., & Farge, E., « Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos », in Sci. Signal 2, ra16, 2009.

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